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Therapeutic effect of polydatin graphene hydrogel on intestinal injury
Yunan Gao1, Xuan Ding2, Baoying Yuan1
1Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Objective:
To prepare a polydatin graphene hydrogel (PD@GO-PAA) that can be orally administered and released in the intestinal tract in a sustained manner for the treatment of intestinal radiation injury.
Methods:
A drug carrier of GO-PAA hydrogel with good swelling ability was prepared by graphene oxide (GO) activation through a hexamethylene diisocyanate and an ammonium esterification reaction with polyacrylic acid (PAA). The physical and chemical properties were characterized using transmission electron microscopy and X-ray diffraction (XRD) analysis. The swelling and drug loading properties of the hydrogels were subsequently tested. The therapeutic effect of PD@GO-PAA on intestinal radiation injury was evaluated using cell viability tests and mouse experiments.
Results:
Physicochemical characterization confirmed that GO-PAA was successfully synthesized and had excellent swelling properties. GO-PAA is slowly released into the intestinal tract of mice and has no toxic effect on cells. The PD@GO-PAA hydrogel protects intestinal epithelial cells, prolongs their survival, alleviates the decrease in peripheral blood cells, and have a good therapeutic effect on intestinal radiation injury.
Conclusion:
The sustained release of the PD@GO-PAA hydrogel enhances the curative effect of polydatin and can be used as a new method for the treatment of intestinal radiation injury.
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