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Adenomyosis is associated with proliferative endometrial disorders
Francesco La Torre1, Yannick Hurni2, Elisa Farsi1
1Division of Obstetrics and Gynecology, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Careggi University Hospital, Florence, Italy.
F&S Science
|March 9, 2026
Summary
Adenomyosis is independently linked to proliferative endometrial disorders, including endometrial intraepithelial neoplasia. This association suggests adenomyosis may increase the risk of these conditions, especially with other risk factors present.
Area of Science:
- Gynecologic Pathology
- Reproductive Endocrinology
Background:
- Adenomyosis is a common benign gynecologic disorder.
- Proliferative endometrial disorders are precursors to endometrial cancer.
- The relationship between adenomyosis and endometrial lesions requires further investigation.
Purpose of the Study:
- To determine the prevalence of proliferative endometrial disorders in women with adenomyosis.
- To evaluate the independent association between adenomyosis and specific endometrial lesions.
Main Methods:
- Retrospective cohort study of 734 patients undergoing hysterectomy.
- Histological records were reviewed to identify adenomyosis and endometrial disorders.
- Multivariable analysis was used to assess independent associations.
Main Results:
- Adenomyosis was present in 34.7% of cases.
- Proliferative endometrial disorders were more common in patients with adenomyosis (37.6% vs. 25.1%).
- Adenomyosis showed independent associations with endometrial polyps, hyperplasia without atypia, and endometrial intraepithelial neoplasia.
Conclusions:
- An independent histopathological association exists between adenomyosis and proliferative endometrial disorders.
- Adenomyosis, particularly with other risk factors, may warrant targeted endometrial assessment due to increased risk of lesions like EIN.
Keywords:
AdenomyosisEndometrial Cancer (EC)Endometrial Hyperplasia Without Atypia (EHWA)Endometrial Intraepithelial Neoplasia (EIN)Endometrial Polyps (EPs)More Related Videos
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