Related Experiment Video

Updated: Mar 10, 2026

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment
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Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

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The function of mRNA quality control in aging and age-related diseases

Seokjun G Ha1, Hyunwoo C Kwon1, Jongsun Lee1

  • 1Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

The Journal of Biological Chemistry
|March 9, 2026
PubMed

Insights

mRNA quality control pathways, like nonsense-mediated mRNA decay (NMD), nonstop decay (NSD), and no-go decay (NGD), are crucial for healthy aging and preventing age-related diseases by clearing faulty transcripts.

Area of Science:

  • Molecular Biology
  • Genetics
  • Aging Research

Background:

  • Aging is a natural process involving functional decline and increased disease risk.
  • mRNA quality control mechanisms are increasingly recognized for their role in aging and longevity.
  • Aberrant transcripts can accumulate and contribute to age-related pathologies.

Purpose of the Study:

  • To review the function of key mRNA surveillance pathways in aging.
  • To explore the roles of nonsense-mediated mRNA decay (NMD), nonstop decay (NSD), and no-go decay (NGD) in age-related diseases.
  • To discuss the potential of targeting these pathways for therapeutic interventions.

Main Methods:

  • Literature review of mRNA surveillance mechanisms and aging.
  • Analysis of the roles of NMD, NSD, and NGD in cellular aging.
  • Exploration of ribosome-associated quality control (RQC) in aging processes.

Main Results:

  • NMD, NSD, and NGD pathways are vital for maintaining mRNA quality during aging.
  • Dysfunction in these pathways is linked to aging and diseases like cancer and neurodegeneration.
  • These mechanisms prevent the buildup of harmful mRNA and protein products.

Conclusions:

  • mRNA surveillance pathways are critical regulators of aging and longevity.
  • Targeting NMD, NSD, and NGD offers potential therapeutic strategies for age-related diseases.
  • Further research into mRNA quality control could unlock new anti-aging interventions.
Keywords:
NMDRQCage-related diseasesagingmRNA quality

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