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COPD and kidney disease: not so far apart?
Iuliana Stratan1, Serghei Covantsev2, Alexander G Mathioudakis3
1Victor Babes University of Medicine and Pharmacy, Timisoara, Piata Eftimie Murgu, Nr. 2, CP 300041, Romania.
Respiratory Medicine
|March 9, 2026
Summary
This review explores the link between Chronic Obstructive Pulmonary Disease (COPD) and Chronic Kidney Disease (CKD). Early screening and multidisciplinary care are crucial for managing this dual burden and improving patient outcomes.
Area of Science:
- Pulmonary Medicine
- Nephrology
- Epidemiology
Background:
- The association between COPD and CKD is increasingly recognized.
- Shared risk factors like age and smoking contribute to both conditions.
- Novel biomarkers and epigenetics may bridge the lung-kidney axis.
Purpose of the Study:
- To synthesize current literature on the COPD-CKD association.
- To examine the impact of CKD on COPD management and vice versa.
- To advocate for improved detection and care strategies.
Main Methods:
- Literature review of epidemiological, mechanistic, and clinical studies.
- Evaluation of established and emerging risk factors.
- Analysis of clinical management implications and patient outcomes.
Main Results:
- COPD and CKD share risk factors and influence each other's progression.
- CKD affects COPD management (drug dosing, acid-base balance).
- COPD can impair renal function, increasing cardiovascular risks and mortality.
Conclusions:
- Early detection and screening (creatinine, cystatin C) are vital.
- A multidisciplinary approach is recommended for patients with dual COPD and CKD.
- Future research should focus on standardized screening and targeted therapies.
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