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Published on: May 26, 2023
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Metal-organic frameworks for topical and transdermal therapeutics.
Yu-Ru Chen1, Ruoshi Wang1, Yue Lin1
1Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China.
Summary
Metal-organic frameworks (MOFs) offer advanced solutions for topical and transdermal drug delivery, overcoming limitations of conventional methods. MOF integration into various matrices promises intelligent, personalized dermatological therapies.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Conventional topical and transdermal formulations exhibit limitations in drug penetration and release kinetics.
- Dermatological and mucosal disorders require advanced therapeutic strategies for effective management.
Purpose of the Study:
- To review the characteristics and advantages of MOF-based topical and transdermal formulations.
- To summarize the applications of MOFs in various topical and transdermal drugs.
- To discuss the application value and challenges of MOF-based delivery systems.
Main Methods:
- Literature review of MOF applications in topical and transdermal drug delivery.
- Analysis of MOF properties including stimuli-responsiveness, drug loading, and multifunctionality.
- Examination of MOF integration with biocompatible matrices like hydrogels and microneedles.
Main Results:
- MOFs provide enhanced drug penetration, controlled release, and responsiveness to pathological microenvironments.
- Integration of MOFs into matrices improves mechanical adaptability and biosafety of formulations.
- MOFs demonstrate significant potential for targeted and comprehensive dermatological therapies.
Conclusions:
- MOF-based formulations represent a promising advancement over conventional methods for topical and transdermal delivery.
- Future applications include intelligent, personalized wound care and dermatological treatments.
- Challenges in long-term biocompatibility, scalable fabrication, and clinical translation require further investigation.
Keywords:
HydrogelsMetal-organic frameworksMicroneedlesNanofibersSprayTopical drug deliveryWound healingMore Related Videos
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