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Updated: Mar 10, 2026

Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors
Published on: February 19, 2022
Enucleation and Esophagectomy for Esophageal Gastrointestinal Stromal Tumors: A Systematic Review
Hai-Dong Zhang1, Ming-Chun Mu2, Xiao-Nan Yin2
1Colorectal Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Abstract:
Surgery remains curative for esophageal gastrointestinal stromal tumors (GISTs), while debates persist between minimally invasive enucleation and radical esophagectomy. Limited evidence from case reports and small cohorts necessitates a systematic evaluation to guide clinical decisions. This review showed that enucleation may be considered for small and low-mitotic-index esophageal GISTs with benign tendency. Despite higher R1 and tumor rupture rates, survival outcomes were comparable to esophagectomy. Enucleation, including endoscopic enucleation, was safe and effective in selected cases.
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