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Updated: Mar 10, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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VEGF-C-Driven Lymphatic Survival Signaling Promotes Periodontal Repair.

S Matsumoto1, T Iwayama1, P Bhongsatiern1,2,3

  • 1Department of Periodontology and Regenerative Dentistry, Graduate School of Dentistry, The University of Osaka, Osaka, Japan.

Journal of Dental Research
|March 9, 2026
PubMed
Summary
This summary is machine-generated.

Lymphatic vessels actively rebuild during periodontal healing, promoting tissue repair. Stimulating lymphangiogenesis with VEGF-C enhances alveolar bone regeneration, offering a new therapeutic approach for gum disease.

Keywords:
alveolar bone losscell survivallymphangiogenesisperiodontitisvascular endothelial growth factor receptor-3

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Area of Science:

  • Oral Biology
  • Regenerative Medicine
  • Lymphatic Biology

Background:

  • The role of lymphatic vessels in periodontal healing is not well understood.
  • Periodontal disease affects gum tissues and supporting bone structures.

Purpose of the Study:

  • To investigate lymphatic vessel dynamics during periodontal wound repair.
  • To explore the therapeutic potential of targeting lymphatics for enhanced periodontal regeneration.

Main Methods:

  • Utilized Prox1-tdTomato mice, tissue clearing, and light sheet microscopy for 3D imaging of gingival lymphatics.
  • Administered VEGF-C agonist to assess impact on lymphatic function and bone repair.
  • Established primary cultures of gingiva-derived lymphatic endothelial cells (LECs) for molecular analysis.

Main Results:

  • Observed active lymphatic reassembly and increased density in the marginal gingiva during healing.
  • VEGF-C stimulation enhanced lymphatic function and promoted alveolar bone repair.
  • Gingival LECs exhibited unique transcriptomic profiles and responded to VEGF-C, with modulated apoptosis-related genes.

Conclusions:

  • Lymphatic vessels play a significant regenerative role in the periodontium.
  • Targeting lymphangiogenesis is a promising strategy for periodontal repair.
  • Primary gingival LEC cultures provide a valuable tool for studying oral lymphatic biology.