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Related Concept Videos

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Related Experiment Video

Updated: Mar 10, 2026

The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
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Discoidin Domain Receptor 2 Is Required for Tooth Extraction Socket Healing.

R A Kamath1,2, A Phanrungsuwan3, C Ge1

  • 1Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.

Journal of Dental Research
|March 9, 2026
PubMed
Summary
This summary is machine-generated.

Discoidin Domain Receptor 2 (DDR2) is crucial for alveolar bone healing after tooth extraction. Its absence impairs socket repair by reducing cell proliferation and disrupting collagen structure, highlighting its therapeutic potential.

Keywords:
bone biologybone remodeling and regenerationcell-matrix interactionscollagenscraniofacial biology and geneticsextracellular matrix

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Regenerative Medicine

Background:

  • Discoidin Domain Receptor 2 (DDR2) is a tyrosine kinase vital for bone development and regeneration.
  • DDR2's role in alveolar bone healing remained unexplored despite its expression in this tissue.

Purpose of the Study:

  • To investigate the function of DDR2 in alveolar bone formation during tooth socket healing.
  • To determine the cellular contribution of DDR2-expressing cells to socket repair.

Main Methods:

  • Utilized global and conditional knockout mouse models (Ddr2LacZ/LacZ, Gli1CreERT2; Ddr2fl/fl) and lineage tracing (Ddr2mer-cre-mer; R26RtdTomato, Gli1CreERT2; R26RtdTomato).
  • Analyzed tooth socket healing post-extraction through histological assessments, cell proliferation assays, apoptosis detection, and collagen fibril orientation analysis.

Main Results:

  • Global Ddr2 deficiency significantly impaired socket healing, marked by reduced cell proliferation and disrupted collagen organization.
  • Lineage tracing revealed that both DDR2+ and GLI1+ cells contribute to socket healing, with DDR2 likely functioning within GLI1+ skeletal progenitor cells.
  • Conditional knockout of Ddr2 in Gli1+ cells partially inhibited socket repair, confirming DDR2's role in these progenitor cells.

Conclusions:

  • DDR2 plays a significant role in alveolar bone repair following tooth extraction.
  • DDR2's function in GLI1+ progenitor cells is critical for effective socket healing.
  • These findings suggest DDR2 as a potential therapeutic target for alveolar bone loss conditions.