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Should Injectable Meloxicam Be Approved for Use in Cats?

Matthew K Wun^1,2,3, Michael H Court¹, Nicolas F Villarino¹

¹Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.

Journal of Veterinary Pharmacology and Therapeutics

|March 9, 2026

Summary

This summary is machine-generated.

Injectable meloxicam use in cats is linked to acute kidney injury (AKI). Data on this risk, found in a regulatory submission, was excluded from the published study, raising ethical concerns about drug promotion.

Keywords:

NSAID acute kidney injury adverse drug reactions research integrity

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Area of Science:

Veterinary Pharmacology
Animal Toxicology
Drug Safety Evaluation

Background:

Injectable meloxicam is frequently used in feline medicine.
This NSAID has a known association with acute kidney injury (AKI) in cats.
Concerns exist regarding the transparency of safety data in veterinary drug trials.

Purpose of the Study:

To examine the omission of critical safety data from a published veterinary clinical trial.
To question the approval process and industry influence on meloxicam prescribing.
To highlight ethical considerations in pharmaceutical-sponsored veterinary research.

Main Methods:

Review of a New Animal Drug Application (NADA) Freedom of Information Summary.
Comparison of data submitted to the U.S. Food and Drug Administration (FDA) versus the published study.
Analysis of financial sponsorship and its potential influence on veterinary organizations and practices.

Main Results:

Data linking injectable meloxicam to AKI in cats were present in the FDA submission.
These specific data regarding AKI were omitted from the published version of the clinical trial.
The study was financially sponsored by the drug manufacturer, raising ethical questions.

Conclusions:

The omission of AKI data from the published meloxicam trial warrants scrutiny.
Pharmaceutical industry sponsorship may influence veterinary prescribing and policy.
There is a need for greater transparency in veterinary drug trial reporting and ethical oversight.