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Updated: Mar 10, 2026
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Published on: August 15, 2025
Clinical Features of Solitary Fibrous Tumor: Insights From a Single Center Experience
Chenglong Zhou1, Lijuan Zhang2, Hui Wang3
1Department of Medical Imaging, Shengli Oilfield Central Hospital, Dongying City, Shandong, China.
Background And Objectives:
This study investigates the clinical characteristics, pathological features, immunohistochemical profiles, and prognostic factors of solitary fibrous tumors (SFTs) to provide insights into their management and prognosis.
Methods:
A retrospective analysis was conducted on 43 cases of SFTs diagnosed at a single center. Patient demographics, tumor characteristics, immunohistochemical (IHC) markers, and outcomes were collected.
Results:
Among the 43 cases, the majority of tumors were infratentorial (81%), and 60% were classified as WHO Grade 1. IHC analyses revealed high expression rates of STAT6 (62.5%), CD34 (82.5%), and Ki-67 (100%). Ki-67 demonstrated the strongest correlation with tumor grade and risk scores (r = 0.62, p < 0.001; r = 0.68, p < 0.001), indicating its role as a significant prognostic marker. CD34 and STAT6 also showed moderate correlations with tumor aggressiveness. Metastatic presentations were noted in 57.5% of cases. The study highlights the heterogeneity of SFTs and the importance of IHC markers in risk stratification.
Conclusion:
The findings underscore the utility of IHC markers, particularly Ki-67, STAT6, and CD34, in assessing the aggressiveness and prognosis of SFTs. Future studies should focus on multicenter validations, integration of advanced molecular diagnostics, and long-term follow-up to refine risk models and therapeutic strategies.
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