Related Experiment Video
Updated: Mar 10, 2026
05:33
High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
Published on: November 9, 2020
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Targeted Protein Degradation by Repurposing Transmembrane E3 Ubiquitin Ligases
Jibin Cui1, Qian Qu1, Man Pan1
1Institute of Translational Medicine, School of Chemistry and Chemical Engineering, Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target, Shanghai Jiao Tong University, Shanghai, China.
Chembiochem : a European Journal of Chemical Biology
|March 9, 2026
Summary
Targeted protein degradation (TPD) is a novel therapeutic approach. New TPD technologies now target cell-surface proteins, enabling the degradation of previously undruggable membrane proteins.
Area of Science:
- Biochemistry
- Molecular Biology
- Drug Discovery
Background:
- Targeted protein degradation (TPD) utilizes cellular machinery to eliminate disease-related proteins.
- Current TPD strategies focus on intracellular proteins.
- Cell-surface proteins represent a largely untapped therapeutic target.
Purpose of the Study:
- To review the advancements in TPD technologies.
- To highlight TPD strategies targeting cell-surface proteins.
- To discuss the potential of targeting the undrugged proteome.
Main Methods:
- Exploiting proximity-induced ubiquitination.
- Utilizing E3 ubiquitin ligases.
- Developing novel TPD modalities for membrane proteins.
Main Results:
- Expansion of TPD to target cell-surface proteins.
- Development of TPD technologies for membrane protein degradation.
- Opening new avenues for therapeutic intervention.
Conclusions:
- TPD is a rapidly evolving field with significant therapeutic potential.
- Targeting cell-surface proteins with TPD offers a new frontier in drug discovery.
- Further development of TPD technologies will broaden the scope of treatable diseases.
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