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Photoresponsive Liquid Grippers for Multi-Dimensional Droplet Manipulation.

Yu Pu1, Lixin Jiang1, Xin Qing1

  • 1College of Smart Materials and Future Energy, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, P. R. China.

Small Methods
|March 9, 2026
PubMed
Summary

Researchers developed a novel bilayer photoresponsive liquid gripper (PLG) for precise 3D droplet manipulation. This technology enables non-destructive capture and release of high-viscosity fluids, advancing microfluidics and biochemical analysis.

Keywords:
droplet manipulationliquid crystal polymersliquid grippersphotodeformationwettability

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Area of Science:

  • Microfluidics and Lab-on-a-Chip Technologies
  • Biomedical Engineering
  • Materials Science

Background:

  • Precise 3D droplet manipulation on open surfaces remains a significant challenge.
  • Existing methods often struggle with high-viscosity fluids and arbitrary control.
  • Need for advanced tools in microfluidics, medical diagnostics, and biochemical assays.

Purpose of the Study:

  • To introduce a novel bilayer photoresponsive liquid gripper (PLG) for precise 3D droplet manipulation.
  • To demonstrate sustainable capture and release of high-viscosity fluids.
  • To enable selective droplet capture for screening and various biochemical applications.

Main Methods:

  • Development of a bilayer gripper integrating an adhesive and an actuation layer.
  • Utilizing a superhydrophobic microarrayed polydimethylsiloxane surface for non-destructive capture.
  • Employing photo-induced bending of photodeformable crosslinked liquid crystal polymers for droplet release.
  • Adjusting surface microstructures for selective droplet size capture.

Main Results:

  • Successful non-destructive capture and release of droplets using the PLG.
  • Demonstrated precise 3D manipulation of high-viscosity fluids like blood and serum.
  • Achieved selective capture of droplets based on size.
  • Validated utility through successful biochemical reactions including blood detection and immunoassays.

Conclusions:

  • The bilayer photoresponsive liquid gripper (PLG) offers a versatile platform for precise 3D droplet manipulation.
  • PLG enables sustainable and non-destructive handling of various fluids, including biological samples.
  • The system shows significant potential for advanced microfluidic applications, biological analysis, and routine biochemical investigations.