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CAR T cells in chronic lymphocytic leukemia: a long unusual journey?

Khalil Saleh1, Hampig Raphael Kourie2, Fadi G Haddad3

  • 1International Department, Gustave Roussy Cancer Campus, Villejuif, France.

Chinese Clinical Oncology
|March 9, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
CAR T-cellChronic lymphocytic leukemia (CLL)ZUMA-8brexucabtagene autoleucellisocabtagene maraleucel

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...