Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phase Transitions: Melting and Freezing02:39

Phase Transitions: Melting and Freezing

15.4K
Heating a crystalline solid increases the average energy of its atoms, molecules, or ions, and the solid gets hotter. At some point, the added energy becomes large enough to partially overcome the forces holding the molecules or ions of the solid in their fixed positions, and the solid begins the process of transitioning to the liquid state or melting. At this point, the temperature of the solid stops rising, despite the continual input of heat, and it remains constant until all of the solid is...
15.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Brittle to Elastic: Substituent Effects on Mechanical Flexibility in Aromatic Amide Crystals.

Chemistry, an Asian journal·2026
Same author

Helically twistable cyanoacrylate crystal with simultaneous photomechanical bending.

Chemical communications (Cambridge, England)·2026
Same author

Reversible twisting-induced crystalline-polycrystalline transformation in cyanoacrylate crystals.

Chemical communications (Cambridge, England)·2025
Same author

Water-driven modulation of multiresponsive properties in acylhydrazone-based crystals.

Chemical communications (Cambridge, England)·2025
Same author

Photo-Induced Cracking in a Bi-Component Molecular Solid: Capturing Structural Intermediates.

Chemistry, an Asian journal·2025
Same author

Recent Advances in Nanomechanical Measurements and Their Application for Pharmaceutical Crystals.

Molecular pharmaceutics·2023

Related Experiment Video

Updated: Mar 10, 2026

High-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal
06:24

High-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal

Published on: October 31, 2019

6.9K

Solvo-Mechanical Flexing in Cryogenically 2D Flexible Single-Crystal-to-Single-Crystal Polymorphic Switch.

Aritra Bhowmik1,2, Jagruti Kurkure3, Manish Kumar Mishra1,2

  • 1Physical and Materials Chemistry Division, CSIR-National Chemical Laboratory, Pune, India.

Small (Weinheim an Der Bergstrasse, Germany)
|March 9, 2026
PubMed
Summary

Researchers discovered stimuli-responsive molecular crystals that bend and transform. This study reveals a rare flexible-to-brittle pathway in indomethacin polymorphs, paving the way for novel smart materials.

Keywords:
2D Elasticitypolymorphismresponsive crystalssolvo‐mechanical bending

More Related Videos

Effect of Bending on the Electrical Characteristics of Flexible Organic Single Crystal-based Field-effect Transistors
08:43

Effect of Bending on the Electrical Characteristics of Flexible Organic Single Crystal-based Field-effect Transistors

Published on: November 7, 2016

8.5K
A Fabrication and Measurement Method for a Flexible Ferroelectric Element Based on Van Der Waals Heteroepitaxy
10:40

A Fabrication and Measurement Method for a Flexible Ferroelectric Element Based on Van Der Waals Heteroepitaxy

Published on: April 8, 2018

8.7K

Related Experiment Videos

Last Updated: Mar 10, 2026

High-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal
06:24

High-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal

Published on: October 31, 2019

6.9K
Effect of Bending on the Electrical Characteristics of Flexible Organic Single Crystal-based Field-effect Transistors
08:43

Effect of Bending on the Electrical Characteristics of Flexible Organic Single Crystal-based Field-effect Transistors

Published on: November 7, 2016

8.5K
A Fabrication and Measurement Method for a Flexible Ferroelectric Element Based on Van Der Waals Heteroepitaxy
10:40

A Fabrication and Measurement Method for a Flexible Ferroelectric Element Based on Van Der Waals Heteroepitaxy

Published on: April 8, 2018

8.7K

Area of Science:

  • Materials Science
  • Crystallography
  • Mechanics

Background:

  • Stimuli-responsive molecular crystals coupling mechanical flexibility and phase transformations are rare.
  • Such materials are promising for smart material applications.

Purpose of the Study:

  • To report a solvo-mechanical bending-induced single-crystal-to-single-crystal (SCSC) transformation in an indomethacin (IND) polymorph.
  • To integrate two-dimensional (2D) elastic flexibility with polymorphic switching.

Main Methods:

  • In situ time-resolved atomic force microscopy (AFM) to capture transformations.
  • Mechanical strain analysis and energy framework calculations.
  • Comparative studies with different indomethacin polymorphs.

Main Results:

  • A 2D elastically bendable methanol solvate crystal of indomethacin (INDM) transforms into the IND-δ polymorph upon heating, retaining crystallinity and elasticity.
  • IND-δ exhibits mechanical flexibility across various temperatures.
  • A flexible-to-flexible-to-brittle polymorphic pathway (INDM → IND-δ → IND-γ) was established.
  • Interactions like hydrogen bonding, π-π stacking, and halogen bonds enable directional elasticity.
  • Indomethacin-delta and indomethacin-alpha demonstrate elasticity, contrary to previous reports.

Conclusions:

  • This work demonstrates novel dynamic mechanical characteristics of indomethacin polymorphs.
  • It offers new directions for designing adaptive crystalline materials with tunable mechanical properties.