A kidney transplant recipient with shingles and necrotizing bacterial superinfection: a case report
Anna Garstenauer1, Raffael Scharinger2, Christof Aigner1
1Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Abstract:
We report a 45-year-old kidney transplant recipient who developed primary varicella zoster virus infection complicated by monomicrobial necrotizing skin and soft tissue infection caused by Pseudomonas aeruginosa. Progressive facial and oropharyngeal edema led to airway compromise requiring endotracheal intubation. Blood and wound cultures grew Pseudomonas aeruginosa, and targeted therapy with meropenem resulted in clinical improvement. The patient recovered with preserved allograft function but was left with residual facial nerve palsy. Pseudomonas aeruginosa-associated monomicrobial necrotizing skin and soft tissue infections are rare, occur predominantly in immunocompromised patients, and can be life-threatening.
Insights
A kidney transplant patient developed a rare, life-threatening skin infection caused by Pseudomonas aeruginosa following varicella zoster virus. Prompt meropenem treatment led to recovery but with residual facial nerve palsy.
Area of Science:
- Nephrology
- Infectious Diseases
- Dermatology
Background:
- Primary varicella zoster virus (VZV) infection is a known complication in kidney transplant recipients.
- Immunocompromised individuals are susceptible to severe bacterial infections.
- Pseudomonas aeruginosa can cause severe necrotizing skin and soft tissue infections (SSTIs).
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