Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurulation01:30

Neurulation

46.9K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
46.9K
Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

8.2K
Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
8.2K
Glial Cells01:04

Glial Cells

95.9K
Overview
95.9K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

1.9K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Foxp1 suppresses cortical angiogenesis and attenuates HIF-1alpha signaling to promote neural progenitor cell maintenance.

EMBO reports·2024
Same author

C<sub>2</sub>H<sub>2</sub>-Type Zinc Finger Proteins in Brain Development, Neurodevelopmental, and Other Neuropsychiatric Disorders: Systematic Literature-Based Analysis.

Frontiers in neurology·2020
Same author

Foxp1 Regulates Neural Stem Cell Self-Renewal and Bias Toward Deep Layer Cortical Fates.

Cell reports·2020
Same author

Development of the medial hypothalamus: forming a functional hypothalamic-neurohypophyseal interface.

Current topics in developmental biology·2013
Same author

Direct and indirect roles of Fgf3 and Fgf10 in innervation and vascularisation of the vertebrate hypothalamic neurohypophysis.

Development (Cambridge, England)·2013
Same author

Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS.

Neuron·2012

Related Experiment Video

Updated: Mar 10, 2026

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain
04:17

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain

Published on: March 8, 2024

1.6K

Radial glia at the neurovascular interface during cortical development.

Njoud Al-Naama1, Caroline Alayne Pearson1

  • 1Center for Neurogenetics and the Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, United States.

Frontiers in Cellular Neuroscience
|March 9, 2026
PubMed
Summary

Radial glia, crucial neural progenitor cells, interact with the developing cortical vasculature. This crosstalk influences brain development by altering the microenvironment and regulating radial glial biology.

Keywords:
angiogenesiscortex developmentendothelial cell (EC)neural stem/progenitor cellsneurogenesis

More Related Videos

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM
09:25

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

Published on: May 8, 2020

11.4K
Neonatal Pial Surface Electroporation
06:22

Neonatal Pial Surface Electroporation

Published on: May 7, 2014

14.4K

Related Experiment Videos

Last Updated: Mar 10, 2026

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain
04:17

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain

Published on: March 8, 2024

1.6K
Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM
09:25

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

Published on: May 8, 2020

11.4K
Neonatal Pial Surface Electroporation
06:22

Neonatal Pial Surface Electroporation

Published on: May 7, 2014

14.4K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Radial glia are essential neural progenitor cells in the developing brain.
  • Their microenvironment dynamically changes throughout development, influencing cortical formation.
  • The developing cortical vasculature significantly impacts the radial glia niche.

Purpose of the Study:

  • To discuss the crosstalk between radial glia and the cortical vasculature.
  • To explore how angiogenic processes influence radial glia.
  • To understand the spatial relationships between radial glia and endothelial cells.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of developmental processes in the cerebral cortex.
  • Examination of cell-cell interactions between glia and vasculature.

Main Results:

  • The establishment of the cortical vasculature alters the radial glia microenvironment.
  • Oxygen and metabolite delivery are increased by vascularization.
  • A close spatial relationship exists between radial glia and endothelial cells, regulating glial biology.

Conclusions:

  • Crosstalk between radial glia and endothelial cells is vital for cortical development.
  • Angiogenesis plays a key role in modulating the radial glia niche.
  • Further research into these intricate spatial relationships is warranted.