Related Experiment Video

Updated: Mar 10, 2026

Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing
05:27

Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing

Published on: January 26, 2024

1.7K

Osteolineage cells ablation promotes skin aging phenotypes via dysregulated bone marrow macrophages

Sen-Yao Zhang1,2, Zhi-Kai Zheng1,2, Fang Ye3,4

  • 1Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.

Iscience
|March 9, 2026
PubMed

Insights

Bone loss accelerates skin aging by affecting bone marrow macrophages, which then impact skin health. This study reveals a new skeletal-immune-skin axis influencing aging.

Area of Science:

  • Gerontology
  • Dermatology
  • Immunology

Background:

  • Clinical observations link bone loss to skin thinning in aging.
  • The specific role of bone in regulating skin aging remains largely unknown.

Purpose of the Study:

  • To investigate the causal relationship between bone health and skin aging.
  • To elucidate the mechanisms by which bone influences skin aging.

Main Methods:

  • Partial ablation of osteolineage cells in a model system.
  • Single-cell RNA sequencing of bone marrow and skin.
  • Analysis of skin aging markers, wound healing, and hair regeneration.
  • Integration with existing skin aging datasets.

Main Results:

  • Osteolineage cell ablation induced skin aging phenotypes, including dermal thinning and impaired regeneration.
  • Bone marrow macrophages exhibited pro-inflammatory activation, metabolic issues, and enhanced SASP signaling.
  • Dysfunctional macrophages infiltrated the skin, causing aging-like changes in skin cells and inflammation.
  • These changes mirrored key molecular features of natural skin aging.

Conclusions:

  • Bone plays a critical role in regulating skin aging through a skeletal-immune-skin axis.
  • Bone marrow macrophage dysfunction is a key mediator linking bone health to skin aging.
  • Maintaining bone homeostasis may be crucial for preventing or mitigating skin aging.
Keywords:
Immunology

More Related Videos

Bone Marrow-derived Macrophage Production07:06

Bone Marrow-derived Macrophage Production

Published on: November 22, 2013

75.6K
Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation07:00

Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation

Published on: August 23, 2018

6.6K

Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
6.5K
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.8K
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.8K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.5K
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
3.2K
Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
9.2K