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Updated: Jul 15, 2026

Catalytic Scavenging of Plant Reactive Oxygen Species In Vivo by Anionic Cerium Oxide Nanoparticles
Published on: August 26, 2018
Reactive Oxygen Species Scavenging Capacity of Functional Fullerenes in Solution and in Macrophage Cells
Rohin Biswas1, Brock J Manley2, Li Xiao2
1Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 123 Bevier Rd, Piscataway, NJ 08854, United States.
Abstract:
Fullerene derivatives are known radical scavengers and quenchers of reactive oxygen species (ROS) and have been studied as promising antioxidative agents in biological systems, yet the correlation between the structural features and their efficiency have not been well understood. In this report, we synthesized eight representative water-soluble fullerene derivatives and compared their radical scavenging properties via electron paramagnetic resonance (EPR) in solution and antioxidative capacity in H2O2-treated RAW 264.7 macrophage cell model. Through this systematic study, we identified multiple key parameters contributing to their radical scavenging and antioxidative effects, including the number and identity of functional groups on the C60 cage, the size of aggregates and their cellular uptake in RAW 264.7 cells.
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