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Updated: Mar 10, 2026
Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
Investigating the structure and bioactivity of lanthanum coordination compounds
Shantanu Kadam1, Bhushan Dhale2, Bapu Yamgar3
1Department of Chemistry, R.P. Gogate College of Arts and Science and R.V. Jogalekar College of Commerce (Autonomous), Ratnagiri, Maharashtra, India.
None:
Lanthanum metal complexes were synthesized using a classical condensation method by reacting lanthanum nitrate salts with a bidentate ligand in a 1:2:1 molar ratio (M:L:L). The formation and structure of the resulting complexes were confirmed through a combination of analytical techniques, including Fourier transformation infrared spectroscopy, thermal gravimetric analysis, X-ray diffraction, elemental microanalysis, and scanning electron microscopy. The lanthanum complexes synthesized exhibited strong in vitro antimicrobial activity. Antibacterial screening showed inhibition zones of 18-26 mm against Staphylococcus aureus and Escherichia coli, surpassing those of the reference drug ciprofloxacin (16-20 mm). Antifungal studies demonstrated inhibition zones of 15-23 mm against Candida albicans and Aspergillus niger. The MIC values ranged from 25 to 50 μg/mL, indicating high potency. Additionally, moderate antimalarial activity was observed against Plasmodium falciparum (IC50 = 12.4 μM). These findings confirm that lanthanum complexes possess potent antibacterial and antifungal properties, highlighting their promise as potential candidates for novel antimicrobial and antimalarial drug development.
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