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Asymptomatic Trypanosoma cruzi Infection Identified During Blood Donation Screening
Jessica M Ngo1, Aashna N Maknojiya1, Richa Y Patel1
1Infectious Diseases, Texas Tech University Health Sciences Center El Paso Paul L. Foster School of Medicine, El Paso, USA.
Cureus
|March 9, 2026
Summary
Chagas disease diagnosis relies on serologic testing, confirmed by two assays per CDC guidelines. This case shows treatment challenges and the need for better monitoring in chronic American trypanosomiasis.
Area of Science:
- Infectious Diseases
- Parasitology
- Public Health
Background:
- Chagas disease, caused by *Trypanosoma cruzi*, is a growing global health concern, especially in non-endemic areas.
- Chronic Chagas disease often presents asymptomatically, complicating diagnosis and increasing the risk of severe late-stage complications.
- Accurate diagnosis of chronic *T. cruzi* infection requires confirmation with two distinct serologic assays, as recommended by CDC guidelines.
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