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ROS-1 Positive Pleural Adenocarcinoma Diagnosed by Semirigid Thoracoscope Using Cryo-Probe in a Middle-Aged Lady: A
Jyoti Bajpai1, Shubhajeet Roy2, Surya Kant1
1Respiratory Medicine, King George's Medical University, Lucknow, IND.
Cureus
|March 9, 2026
Summary
ROS-1 positive non-small cell lung cancer (NSCLC) is a rare, targetable malignancy. Pleural cryobiopsy improved diagnosis and treatment with crizotinib, showcasing personalized therapy for lung cancer.
Area of Science:
- Oncology
- Thoracic Surgery
- Pulmonology
Background:
- ROS-1 positive non-small cell lung cancer (NSCLC) is a rare (1-2%) but targetable lung malignancy.
- Molecular profiling revolutionizes NSCLC management by identifying driver mutations for personalized therapy.
- Diagnosing pleural neoplasia can be challenging due to nonspecific imaging and cytology, especially in fibrotic pleura.
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