Research Review on Inhibitors of Lumpy Skin Disease Virus: From Biological Characteristics, Drug Repurposing, to...

Area of Science:

• Veterinary Virology
• Antiviral Drug Discovery
• Computational Biology

Background:

• Lumpy skin disease virus (LSDV) poses a significant threat to livestock globally.
• Understanding LSDV replication mechanisms is crucial for developing effective treatments.
• Existing research on poxvirus inhibitors provides a foundation for LSDV-targeted therapies.

Purpose of the Study:

• To review current research on inhibitors targeting LSDV.
• To summarize the biological characteristics and key viral proteins of LSDV.
• To explore the potential of computer-aided drug design (CADD) in discovering novel LSDV inhibitors.

Main Methods:

• Literature review of direct-acting and host-directed poxvirus inhibitors.
• Analysis of inhibitor mechanisms of action and potential viral targets.
• Discussion of CADD methodologies, including virtual screening, for anti-LSDV research.

Main Results:

• Compilation of various poxvirus inhibitors and their modes of action.
• Identification of key LSDV proteins involved in viral replication.
• Exploration of CADD approaches for accelerating the discovery of anti-LSDV agents.

Conclusions:

• There is a need for targeted LSDV inhibitors based on known poxvirus strategies.
• CADD offers a promising avenue for identifying novel antiviral compounds against LSDV.
• Further research integrating computational and experimental methods can expedite the development of LSDV therapeutics.