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Published on: January 31, 2022
EFFECT OF PIOGLITAZONE TREATMENT ON ASPROSIN LEVELS IN PATIENTS WITH DIABETES AND METABOLIC DYSFUNCTION-ASSOCIATED
S Bahçebaşı1, H Sipahioğlu1, A Karabulut1
1Internal Medicine, Kayseri City Hospital.
Pioglitazone effectively treats type 2 diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease (MAFLD), significantly reducing key health markers. However, this treatment does not alter asprosin levels in patients with diabetes and MAFLD.
Area of Science:
- Endocrinology
- Hepatology
- Metabolic Diseases
Background:
- Elevated asprosin levels are observed in type 2 diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease (MAFLD).
- MAFLD is prevalent in individuals with diabetes, highlighting a significant overlap in patient populations.
Purpose of the Study:
- To investigate the impact of pioglitazone treatment on asprosin levels in patients with co-existing diabetes and MAFLD.
- To assess the efficacy of pioglitazone in managing metabolic and liver parameters in this patient group.
Main Methods:
- Blood samples were collected from 25 patients with diabetes and MAFLD at diagnosis and after 6 months of pioglitazone treatment.
- Fifteen healthy volunteers served as controls for comparison.
Main Results:
- Pioglitazone treatment led to significant reductions in glucose, HbA1c, AST, ALT, GGT, ALP, and Fib-4 scores.
- No significant changes in blood asprosin levels were observed in patients after pioglitazone treatment compared to controls.
Conclusions:
- Pioglitazone demonstrates efficacy in treating both diabetes and MAFLD, as evidenced by improvements in metabolic and liver function markers.
- The study suggests that pioglitazone's therapeutic effects in diabetic fatty liver disease are independent of asprosin modulation.
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