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Updated: Mar 10, 2026
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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
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FROM 'NULL CELL ADENOMA' TO REFINED DIAGNOSIS: PITFALLS IN PITUITARY MASS EVALUATION.
M Korkmaz Yilmaz1, M Karagulle2, H Karatay3
1University of Health Sciences, Basaksehir Cam and Sakura City Hospital, Department of Endocrinology and Metabolism.
Acta Endocrinologica (Bucharest, Romania : 2005)
|March 9, 2026
Summary
Null cell adenomas (NCAs) are rare pituitary tumors. Diagnostic challenges arise from potential misclassification, emphasizing the need for thorough evaluation to distinguish them from other pituitary pathologies and metastases.
Area of Science:
- Endocrinology
- Pathology
- Oncology
Background:
- Null cell adenomas (NCAs) were once a distinct pituitary tumor subtype but are now redefined by transcription factor (TF) immunostaining.
- Updated WHO classifications focus on cell lineage, narrowing the spectrum of true NCAs.
