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Updated: Mar 10, 2026
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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
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LABOR-RELATED PAIN MANAGEMENT ACCORDING TO OPIOID RECEPTOR POLYMORPHISMS VARIABILITY.
G V Tănase1,2, A E Tănase3, M Ciocoiu2
1Anesthesiology and Intensive Care Unit, "Grigore T Popa" University of Medicine and Pharmacy, Iasi, Romania.
Acta Endocrinologica (Bucharest, Romania : 2005)
|March 9, 2026
Summary
Genetic variations influence pain perception and opioid response, impacting pain management during pregnancy, childbirth, and postpartum recovery. Understanding these genetic polymorphisms can lead to safer, personalized pain relief strategies.
Area of Science:
- Pharmacogenomics
- Pain Management
- Obstetrics and Gynecology
Background:
- Interindividual variability in pain perception and opioid response is significantly influenced by genetic polymorphisms.
- Managing pain effectively and safely during pregnancy, labor, delivery, and postpartum is a critical clinical challenge.
- Specific gene variations (e.g., OPRM1, CYP2D6, COMT, UGT2B7, ABCB1) affect opioid efficacy, dosage, and adverse events in obstetrical patients.
Purpose of the Study:
- To review current evidence on the impact of pain-related genetic polymorphisms in perinatal and gynecological surgery settings.
- To highlight the risks associated with genetic variations in opioid metabolism, such as under- or over-medication.
- To evaluate the potential of pharmacogenomic insights for developing personalized analgesic strategies.
Main Methods:
- Systematic review of existing literature on genetic polymorphisms and pain management.
- Analysis of studies focusing on labor, cesarean section, postpartum recovery, and onco-gynecological surgery.
- Synthesis of data regarding gene-drug interactions and their clinical implications.
Main Results:
- Genetic polymorphisms in key genes significantly alter opioid pharmacokinetics and pharmacodynamics.
- Variations in genes like CYP2D6 can lead to ultra-rapid or poor metabolizer phenotypes, increasing risks of inadequate pain control or adverse drug reactions.
- Evidence suggests a strong link between specific polymorphisms and variable responses to analgesics in obstetrical and gynecological contexts.
Conclusions:
- Pharmacogenomic knowledge is crucial for optimizing pain management in obstetrics and gynecology.
- Personalized analgesic strategies based on genetic profiles can enhance treatment efficacy and patient safety.
- Further research is needed to fully integrate pharmacogenomics into routine clinical practice for improved perinatal and surgical pain care.
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