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Updated: Mar 10, 2026
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A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
Published on: April 30, 2020
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Psychological Stress Modulates Bone Remodeling Pathways in Normotensive and Hypertensive Rats: A Cellular and
Marina Ribeiro Paulini1, Dimitrius Leonardo Pitol1, Glauce Crivelaro do Nascimento1
1Department of Basic and Oral Biology, School of Dentistry of Ribeirão Preto, University of São Paulo (FORP-USP), Ribeirão Preto 14040-904, Brazil.
ACS Omega
|March 9, 2026
Summary
Psychological stress and hypertension negatively impact bone health by altering bone remodeling. Stress reduces osteoblast activity and increases bone resorption, especially in hypertensive rats, highlighting the need for bone health monitoring.
Area of Science:
- Bone Biology and Physiology
- Endocrinology and Metabolism
- Cardiovascular Disease Research
Background:
- Hypertension and psychological stress are common and can negatively impact bone health.
- The combined effects of hypertension and stress on bone remodeling are not well understood.
Purpose of the Study:
- To investigate the impact of acute and chronic stress on bone structure and remodeling in normotensive and spontaneously hypertensive rats.
- To explore the interaction between hypertension and stress in modulating bone metabolism.
Main Methods:
- Utilized normotensive and spontaneously hypertensive rats exposed to control, acute, or chronic variable stress paradigms.
- Assessed bone remodeling via quantitative histology, immunohistochemistry (VEGF, BSP, OCN, TRAP), and enzyme activity assays (MMP-2, MMP-9).
Main Results:
- Stress exposure reduced osteoblast markers (OCN, BSP) and increased remodeling enzymes (MMP-2, MMP-9) and angiogenic signaling (VEGF).
- Elevated bone resorption (TRAP-positive osteoclasts) was observed in stress-exposed rats.
- Hypertensive rats showed higher basal remodeling and MMP-2, with a heightened response to chronic stress, indicating metabolic vulnerability.
Conclusions:
- Stress significantly alters bone metabolism early, preceding structural changes, by affecting osteoblast activity and resorption.
- Hypertension and stress interact to amplify bone remodeling changes, underscoring the importance of bone health assessment in hypertensive individuals under stress.
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