Related Experiment Video
Updated: Mar 10, 2026
05:27
An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
Published on: June 30, 2021
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Factors influencing gut microbial colonization: A host-microbe-environment interaction perspective.
Yan Zhao1,2, Zhangheng Ren1,2, Qinyu Xu1,2
1Jiangsu Key Laboratory of Marine Bioresources and Environment, Jiangsu Key Laboratory of Marine Biotechnology, Jiangsu Ocean University, Lianyungang, 222005, China.
Current Research in Food Science
|March 9, 2026
Summary
The gut microbiome
Area of Science:
- Microbial ecology and host-microbe interactions.
- Host-microbe symbiosis and dysbiosis.
- Systems biology of the gut microbiome.
Background:
- Gut microbial communities are shaped by host genetics, immunity, and environmental factors.
- Host defenses include mucus, antimicrobial peptides, and secretory IgA.
- Genetic factors like LCT and ABO/FUT2 influence gut microbial composition.
Purpose of the Study:
- To review host barriers, microbial adaptability, and environmental influences on gut microbial colonization.
- To explore interaction frameworks governing microbial community stability and dysbiosis.
- To propose translational strategies for personalized microbiome interventions.
Main Methods:
- Synthesis of evidence on host immunity, genetic loci, and microbial adaptations.
- Evaluation of environmental perturbations and their impact on the gut microbiome.
- Delineation of interaction frameworks like cross-feeding and cross-kingdom crosstalk.
Main Results:
- Host genetics and immunity establish barriers and select microbial strains.
- Microbial adaptability involves nutrient utilization, immune modulation, and adhesion.
- Environmental factors significantly reshape microbial communities and resilience.
- Interaction frameworks dictate community stability and susceptibility to dysbiosis.
Conclusions:
- Niche elasticity is proposed as a metric for microbiome stability and recovery.
- Personalized interventions can be developed using multi-omics and engineered microbes.
- Future strategies involve engineered probiotics, phages, and anti-adhesion approaches.
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