Related Experiment Video
Updated: May 3, 2026
09:33
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
Published on: July 28, 2013
29.4K
Case report: Hemodynamic dynamics in central variant PRES via serial ASL/DTI.
Xueping Lu1,2, Kai Tang3, Qiao Wang4
1Department of Neurology, The Second People's Hospital, Wuhu, Anhui, 241000, China.
Neuroimage. Reports
|March 9, 2026
Summary
Central variant posterior reversible encephalopathy syndrome (PRES) is a rare condition. This study shows biphasic hemodynamic changes in PRES, highlighting autoregulatory failure and using advanced imaging to monitor recovery.
Area of Science:
- Neuroscience
- Radiology
- Vascular Neurology
Background:
- Posterior reversible encephalopathy syndrome (PRES) is a neurological condition.
- Central variant PRES is a rare subtype affecting the brainstem and deep structures.
- This subtype presents with severe hypertension but minimal neurological deficits, posing diagnostic challenges.
Purpose of the Study:
- To present the first longitudinal evidence of acute-phase biphasic hemodynamics in central variant PRES.
- To investigate the underlying mechanisms of cerebrovascular dysregulation in this rare condition.
- To demonstrate the utility of serial imaging in monitoring recovery.
Main Methods:
- Utilized serial arterial spin labeling (ASL) and diffusion tensor imaging (DTI) in a patient with central variant PRES.
- Assessed cerebral blood flow (CBF) in the pons and middle cerebellar peduncle (MCP).
- Monitored fractional anisotropy (FA) changes over time.
Main Results:
- Observed concurrent pontine and right MCP CBF patterns indicating regional perfusion imbalance and autoregulatory failure.
- Demonstrated complementary hemodynamic phenotypes of cerebrovascular dysregulation.
- Showed normalization of CBF and progressive increase in FA post-treatment, indicating recovery.
Conclusions:
- Biphasic hemodynamic changes in central variant PRES support autoregulatory failure as the primary mechanism.
- Serial ASL and DTI serve as valuable biomarkers for monitoring recovery in this rare PRES phenotype.
- Advanced imaging techniques are crucial for understanding and managing central variant PRES.
Related Concept Videos
01:29Blood Flow
57.4K
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
57.4K
01:19Assessing Blood pressure using a doppler ultrasound
3.0K
To obtain accurate blood pressure measurements in clinical settings, especially when traditional methods are insufficient, healthcare professionals utilize the Doppler ultrasound technique. This method uses high-frequency sound waves to detect blood flow within the arteries, which is crucial for patients with conditions that complicate circulatory system assessment.
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
3.0K