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Updated: Mar 10, 2026
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Kinetic Analysis of Vasculogenesis Quantifies Dynamics of Vasculogenesis and Angiogenesis In Vitro
Published on: January 31, 2018
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Cohort Profile: The Youth Vascular Consortium
Jun Young Park1, Vimarsha Kodithuwakku2, Alejandro Diaz3
1Department of Preventive Medicine, Yonsei University College of Medicine, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722 South Korea.
Artery Research
|March 9, 2026
Summary
The Youth Vascular Consortium (YVC) established international standards for assessing vascular health in youth. This enables early detection of cardiovascular risk factors, improving long-term health outcomes.
Area of Science:
- Cardiovascular Health
- Pediatric Cardiology
- Vascular Biology
Background:
- Cardiovascular disease (CVD) is a leading global cause of death, with origins in early life.
- Cardiovascular risk factors and vascular abnormalities in youth predict adult outcomes.
- Lack of reference values and standardized protocols hindered youth vascular assessment.
Purpose of the Study:
- Address gaps in youth vascular assessment through international collaboration.
- Establish standardized definitions and protocols for early vascular aging.
- Develop reference values for key vascular measures in young populations.
Main Methods:
- International collaboration involving 33 research centers across 27 countries.
- Inclusion of 29,704 participants aged 2 to 40 years.
- Assessment of validated vascular measures including pulse wave velocity, central blood pressure, and intima-media thickness.
Main Results:
- Established international expert consensus on early vascular aging definitions.
- Developed evidence-based recommendations for vascular assessment protocols.
- Generated device-specific reference values for pulse wave velocity with age and sex-specific percentile curves.
Conclusions:
- The Youth Vascular Consortium (YVC) provides a platform for studying early-life vascular health.
- Harmonized data and established standards aim to improve pediatric vascular health.
- Facilitates early identification and prevention of modifiable vascular trajectories to reduce lifelong CVD burden.
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