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Updated: Mar 10, 2026

Production of Membrane-Filtered Phase-Shift Decafluorobutane Nanodroplets from Preformed Microbubbles

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How volatile components stabilize bulk nanobubbles: a model study.

Jing Li¹, Zhenjiang Guo², Shuai Xia¹

¹College of Pharmaceutical Engineering, Jining Medical University, Jining, China.

Frontiers in Chemistry

|March 9, 2026

Summary

This summary is machine-generated.

Volatile components stabilize bulk nanobubbles by balancing gas exchange, a crucial mechanism absent in systems with only non-condensable gases. This interaction ensures long-term nanobubble stability.

Keywords:

bulk nanobubbles dynamic equilibrium molecular dynamics simulation stability volatile components

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Area of Science:

Physical Chemistry
Nanotechnology
Fluid Dynamics

Background:

Bulk nanobubbles are widely studied, but the role of volatile components in their stability is not well understood.
Previous research has primarily focused on non-volatile components, leaving a gap in understanding nanobubble longevity.

Purpose of the Study:

To investigate the stabilizing effect of volatile components on bulk nanobubbles.
To elucidate the thermodynamic mechanisms governing the interaction between volatile and non-condensable gases within nanobubbles.

Main Methods:

Development of a thermodynamic model to describe the dynamic equilibrium of gases within nanobubbles.
Validation of the thermodynamic model using molecular dynamics simulations.
Experimental investigation of nanobubble stability under varying gas compositions.

Main Results:

Volatile components establish a negative-feedback mechanism that regulates gas exchange across the nanobubble interface.
This feedback mechanism is essential for achieving long-term stability of bulk nanobubbles.
Systems with only non-condensable gases were unable to sustain stable nanobubbles.

Conclusions:

The synergistic interaction between volatile and non-condensable gases is critical for stabilizing bulk nanobubbles.
Volatile components play a key role in preventing nanobubble dissolution.
Understanding these interactions opens new avenues for controlling nanobubble behavior.