Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

1.5K
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-Mobility Carrier Diffusion Visualization and Dynamic Engineering in Bi<sub>2</sub>O<sub>2</sub>Se Nanoplates.

The journal of physical chemistry letters·2026
Same author

Conjugated Polymer Semiconductors Enabled Multifunctional Interfacial Engineering for High-Performance Inverted Perovskite Solar Cells.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Comprehensive Analysis of the Polygalacturonase Gene Family and Transcriptome Screening for Candidate Genes Associated with Postharvest Softening in Atemoya.

Plants (Basel, Switzerland)·2026
Same author

Structural basis of asymmetric transcription through a composite nucleosome formed by a hexasome and an octasome.

Nature structural & molecular biology·2026
Same author

Hetero-top-grafting impairs carbon allocation and induces defense-related metabolic remodeling at the citrus top graft union.

Plant physiology and biochemistry : PPB·2026
Same author

Clinical efficacy of membrane anatomy-based 3D laparoscopic partial nephrectomy in a single stage for the treatment of ruptured renal angiomyolipoma.

Frontiers in oncology·2026

Related Experiment Video

Updated: Mar 10, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

772

Transcriptomic analysis reveals synaptic dysregulation and mitochondrial dysfunction in autism spectrum disorder.

Xiaoli Liao1,2, Jingqi Shao2, Zhihui Chen3

  • 1Hunan Provincial People's Hospital, Changsha, Hunan, China.

Brain, Behavior, & Immunity - Health
|March 9, 2026
PubMed
Summary

Autism spectrum disorder (ASD) shows altered gene expression linking mitochondrial dysfunction and synaptic problems. This study reveals a molecular signature connecting metabolic disruption and synaptic abnormalities in ASD, offering potential therapeutic targets.

Keywords:
Autism spectrum disorderMitochondrial dysfunctionPathway analysisSynaptic dysregulationTranscriptomic profiling

More Related Videos

Generation and Characterization of Human Induced Pluripotent Stem Cell-derived Astrocytes Lacking Fragile X Messenger Ribonucleoprotein
10:59

Generation and Characterization of Human Induced Pluripotent Stem Cell-derived Astrocytes Lacking Fragile X Messenger Ribonucleoprotein

Published on: June 6, 2025

1.2K
Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

2.6K

Related Experiment Videos

Last Updated: Mar 10, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

772
Generation and Characterization of Human Induced Pluripotent Stem Cell-derived Astrocytes Lacking Fragile X Messenger Ribonucleoprotein
10:59

Generation and Characterization of Human Induced Pluripotent Stem Cell-derived Astrocytes Lacking Fragile X Messenger Ribonucleoprotein

Published on: June 6, 2025

1.2K
Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

2.6K

Area of Science:

  • Neuroscience
  • Genetics
  • Biochemistry

Background:

  • Autism spectrum disorder (ASD) is a complex neurodevelopmental condition.
  • Mitochondrial dysfunction and synaptic abnormalities are implicated in ASD pathophysiology.
  • Understanding the molecular links is crucial for developing effective interventions.

Purpose of the Study:

  • To investigate the molecular relationship between mitochondrial dysfunction and synaptic dysregulation in ASD.
  • To identify gene expression changes and disrupted pathways in ASD.
  • To explore potential biomarkers and therapeutic targets for ASD.

Main Methods:

  • Transcriptomic analysis of peripheral blood samples (GSE18123 dataset).
  • Differential gene expression analysis focusing on neurodevelopmental genes.
  • Functional enrichment (GO, KEGG), protein-protein interaction (PPI) network, and gene co-expression analyses.

Main Results:

  • Identified 27 differentially expressed genes in ASD, with 22 upregulated.
  • Synaptic signaling and mitochondrial oxidative phosphorylation pathways were significantly dysregulated.
  • DKK1 and CYCS identified as central regulatory hubs in PPI networks.
  • Co-expression analysis revealed coordinated dysregulation in synaptic and metabolic networks.

Conclusions:

  • ASD exhibits a distinct molecular signature linking synaptic abnormalities and metabolic disruption.
  • Findings provide insights into ASD pathophysiology.
  • Highlights potential for biomarker development and novel therapeutic strategies for ASD.