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Updated: Mar 10, 2026
05:36
Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
Published on: February 8, 2020
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IFI44 Promotes Clear Cell Renal Cell Carcinoma Progression via PRDX1 and Predicts Poor Prognosis
Yipeng Xu1,2, Renjun Gu3,4, Hao Zhang5
1Department of Urology, Zhejiang Cancer Hospital, Hangzhou, P.R. China.
Research (Washington, D.C.)
|March 9, 2026
Summary
Interferon-induced protein 44 (IFI44) promotes clear cell renal cell carcinoma (ccRCC) progression by interacting with PRDX1 and creating an immunosuppressive tumor environment. IFI44 is a potential prognostic biomarker and therapeutic target for ccRCC.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- Clear cell renal cell carcinoma (ccRCC) is a deadly cancer lacking effective prognostic biomarkers.
- The role of Interferon-induced protein 44 (IFI44) in ccRCC pathogenesis remains largely unknown.
Purpose of the Study:
- To investigate the clinical significance, biological functions, and molecular mechanisms of IFI44 in ccRCC.
- To evaluate IFI44 as a potential prognostic biomarker and therapeutic target for ccRCC.
Main Methods:
- Integrative transcriptomic analysis of ccRCC patient data (GEO and TCGA).
- Bioinformatic enrichment analyses and immune infiltration profiling.
- Functional studies using ccRCC cell lines with IFI44 knockdown and PRDX1 overexpression.
Main Results:
- IFI44 is significantly upregulated in ccRCC tissues and associated with advanced stage and poor survival.
- IFI44 knockdown inhibits ccRCC cell proliferation, migration, and invasion while inducing apoptosis.
- IFI44 interacts with PRDX1, and its overexpression rescues IFI44 knockdown-induced phenotypes.
- IFI44 expression correlates with an immunosuppressive tumor microenvironment.
Conclusions:
- IFI44 functions as an oncogene in ccRCC, promoting tumor progression and immune evasion.
- IFI44 is a promising prognostic biomarker and therapeutic target for ccRCC.
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