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Updated: Mar 10, 2026

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
Published on: April 7, 2023
Upadacitinib for the Treatment of Cutaneous Crohn's Disease Presenting as Lymphangioma Circumscriptum
Benjamin Gerstein1, William C Lau1, Avi Bitterman1
1Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY.
Abstract:
Metastatic Crohn's disease refers to cutaneous Crohn's disease noncontiguous with the gastrointestinal tract. Vulvar lymphangioma circumscriptum is a rare manifestation of metastatic Crohn's disease, presenting as pink papillomatous or vesicular papules and plaques. Treatment options are limited and often invasive, and clearance is difficult to achieve. We report a novel case of vulvar lymphangioma circumscriptum secondary to Crohn's disease successfully managed with oral and topical Janus kinase inhibitors in combination with procedural therapies.
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