Related Experiment Video
Updated: Mar 10, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Orthorhombic polymorph of 4-(2,2':6',2''-terpyridin-4'-yl)aniline
Nicola Edwards1, Shao-Liang Zheng2
1Department of Chemistry, University of St. Joseph, West Hartford, CT, 06032, USA.
This study reports new crystallographic data for C21H16N4, revealing a novel crystal structure with intermolecular hydrogen bonding and pi-pi interactions. The findings offer insights into the compound
Area of Science:
- Crystallography
- Solid-state chemistry
Background:
- Understanding the crystal structures of organic compounds is crucial for predicting their properties.
- Polymorphism in organic molecules can significantly impact their physical and chemical behavior.
Purpose of the Study:
- To report the crystallographic data for the compound C21H16N4.
- To characterize a new crystalline form of the compound and compare it with previously reported polymorphs.
Main Methods:
- Recrystallization from a methanol/acetonitrile solvent system.
- Single-crystal X-ray diffraction at 100 K.
Main Results:
- The compound C21H16N4 crystallizes in the Pca21 space group.
- The structure exhibits intermolecular hydrogen bonding (N-H...N contacts) and pi-pi interactions.
- Non-planar ring structures were observed, with dihedral angles between peripheral rings and the central pyridine ranging from -7.1(3) to 29.8(3)°.
Conclusions:
- The study presents a new crystallographic polymorph for C21H16N4.
- The observed intermolecular interactions and non-planar geometry provide insights into the solid-state packing and potential properties of the compound.
More Related Videos
06:34Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
Published on: June 20, 2014
07:12Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Related Concept Videos
Nomenclature of Aryl and Heterocyclic Amines
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
Aromatic Hydrocarbon Cations: Structural Overview
Removing one hydrogen from the intervening CH2 group...
Aromatic Hydrocarbon Anions: Structural Overview
Due to the absence of continuous...
Basicity of Heterocyclic Aromatic Amines
Structure of Amines