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Updated: Mar 10, 2026
Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
Published on: July 28, 2010
Clinical Significance of Copper Chaperone for Superoxide Dismutase in Colorectal Cancer
Nobuo Takiguchi1, Mamoru Uemura1, Mao Osaki1
1Department of Gastroenterological Surgery, Graduate School of Medicine The University of Osaka Suita Osaka Japan.
Background:
Targeting Cu transport proteins is an innovative therapeutic approach for combating cancer. However, the mechanisms underlying the malignant potential of Cu transport proteins remain largely unknown. To address this issue, we focused on the oncogenic potential of copper chaperones for superoxide dismutase (CCS) in colorectal cancer (CRC).
Methods:
We investigated the association between the prognosis and the copper transport protein, CCS, using clinical samples. The function of CCS was analyzed to assess the proliferation and migration potential of CRC cells.
Results:
Univariate and multivariate analyses revealed that CCS was an independent prognostic factor for disease-free survival and overall survival. CCS is closely related to the malignant potential of CRC, which includes proliferation, migration, and the MEK-ERK pathway.
Conclusions:
Thus, CCS is a valuable biomarker and therapeutic target for CRC.
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