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Role of the RBMS Family in Different Cancers and Research Progress

Hanchi Wu1,2, Rui Hou1,2, Yuhan Zhang1,2

  • 1The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, China.

International Journal of Medical Sciences
|March 9, 2026
PubMed

Insights

RNA-binding proteins (RBPs) regulate RNA and are crucial in cancer. This review details RNA-binding motif single-stranded interacting proteins (RBMSs) roles in various cancers, including breast, lung, and liver.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • RNA-binding proteins (RBPs) are key posttranscriptional regulators controlling RNA processing, localization, modification, and translation.
  • RNA-binding motif single-stranded interacting proteins (RBMSs) are a vital subgroup of RBPs implicated in cellular processes.
  • RBMSs have been linked to tumorigenesis and cancer progression by influencing oncogenes, growth factors, and cell cycle proteins.

Purpose of the Study:

  • To review the multifaceted roles of RBPs in cancer.
  • To highlight the specific involvement of RBMSs in various cancer types.
  • To summarize current research progress on RBPs in oncological diseases.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of studies focusing on RBPs and RBMSs in cancer.
  • Compilation of data on RBP functions in specific cancer types.

Main Results:

  • RBPs significantly impact RNA metabolism and gene expression.
  • RBMSs play critical roles in the development and progression of multiple cancers.
  • Evidence links RBPs to oncogenesis through regulation of key cancer-related genes and proteins.

Conclusions:

  • RBPs, particularly RBMSs, are important therapeutic targets in oncology.
  • Further research into RBP functions can uncover novel strategies for cancer treatment.
  • Understanding RBP roles is crucial for advancing cancer research and patient care.
Keywords:
RNA-binding proteincancertumor microenvironment

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