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Selective Autophagy Mediated by Protein Ubiquitination in Major Prevalent Zoonoses
Chi Meng1, Fengyuan Jiao1, Gengxu Zhou1
1The College of Veterinary Medicine, Southwest University, Chongqing, 402460, China, southwest.edu.
Transboundary and Emerging Diseases
|March 9, 2026
Summary
Zoonotic pathogens disrupt host protein degradation pathways, including the ubiquitin-proteasome system (UPS) and autophagic lysosomal pathway (ALP), to survive and evade immune defenses. Understanding these mechanisms offers new strategies for preventing and treating zoonotic diseases.
Area of Science:
- Immunology
- Microbiology
- Cell Biology
Background:
- Zoonotic diseases pose significant threats to animal and human health.
- Protein ubiquitination and autophagy are crucial cellular defense mechanisms against pathogens.
Purpose of the Study:
- To review how zoonotic pathogens interfere with protein degradation pathways.
- To provide insights into novel therapeutic and preventive strategies for zoonotic diseases.
Main Methods:
- Literature review of pathogen-host interactions.
- Analysis of molecular mechanisms of protein ubiquitination and autophagy evasion.
Main Results:
- Zoonotic pathogens manipulate the ubiquitin-proteasome system (UPS) and autophagic lysosomal pathway (ALP).
- Pathogen interference promotes pathogen replication, survival, and immune evasion.
Conclusions:
- Targeting pathogen-mediated disruption of UPS and ALP presents a promising approach for zoonotic disease control.
- Further research into these evasion mechanisms can lead to effective interventions.
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