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Published on: December 6, 2016
Effectiveness of transoral robotic surgery of the base of the tongue vs. conservative treatment for obstructive sleep
A G L Toppenberg1,2, J van der Maten3, M Bos4
1Department of Otorhinolaryngology - Head and Neck Surgery, University Medical Centre Groningen, Groningen, the Netherlands.
Background:
CPAP is the gold standard treatment for obstructive sleep apnea (OSA) but suffers from poor long-term compliance. Alternatives like mandibular advancement devices (MADs) and surgery, such as transoral robotic surgery (TORS), are available, but their comparative efficacy is unclear.
Study Objective:
This study aims to evaluate whether base of the tongue (BOT) reduction using TORS is equal or superior to CPAP and MADs in improving quality of sleep and life in patients with moderate to severe OSA eligible for surgery.
Study Design:
A prospective randomized controlled trial.
Population:
Patients eligible for TORS and CPAP or MAD aged >18 years with moderate to severe OSA (Apnea Hypopnea Index >15) untreated before.
Interventions:
In total 50 patients, 25 in each treatment arm will be randomized to either TORS or non-surgical therapy (CPAP or MAD depending on preference of patient or physician).
Outcome Measures:
Primary outcomes will include improvement in sleep apnea severity measured through the apnea hypopnea index (AHI) and oxygen desaturation index (ODI)4%. Secondary outcomes will assess long-term quality of life compared to non-surgical therapy and adherence to devices.
Results:
The data will be analysed on an Intention-To-Treat principle (ITT). Ethical approval was obtained from RTPO in September of 2023. Trial registration number: NL84446.099.23 METCnumber UMCG25.327. Outcomes will be published in peer reviewed journals and presented at (inter)national conferences.
Discussion:
Findings of this study will address the evidence gap in the comparative effectiveness of TORS versus non-surgical therapies for OSA and may inform future clinical decision making and guideline development.
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