Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

6.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Operational Data Management Approach for Helicopter-based Aerial Radiation Measurements in Emergency Preparedness and Response.

Health physics·2026
Same author

Glucagon-like peptide-1 receptor agonist prevents pulmonary fibrosis following acute COVID-19 infection associated with type 2 diabetes.

Journal of virology·2026
Same author

Organizational Stressors, Burnout, and Mental Health Outcomes Among Local Government Employees During Disaster Response.

Journal of occupational and environmental medicine·2026
Same author

Caregiver Reports of Lucid Episodes in Alzheimer's Dementia and Lewy Body Dementias.

Journal of geriatric psychiatry and neurology·2026
Same author

Sialic acid-anchored haemagglutinin stalk neutralizing antibody M-SiaB enhances protection against highly pathogenic influenza H5N1/Texas/2024.

Nature communications·2026
Same author

Postbiotic Lactobacillus sakei CVL-001 promotes mucosal tolerance via NOD2-dependent programming of tolerogenic CD11c<sup>+</sup> antigen-presenting cells.

Mucosal immunology·2026

Related Experiment Video

Updated: Mar 10, 2026

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei
09:02

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei

Published on: February 17, 2014

20.3K

Exploring Host-driven Immunopathological Factors Developing Severe Tuberculosis: Insights from Comparative Mouse

Hongmin Kim1, Kee Woong Kwon1,2, Hagyu Kim3

  • 1Department of Microbiology, Institute for Immunology and Immunological Disease, Yonsei University College of Medicine, Seoul, South Korea.

International Journal of Biological Sciences
|March 9, 2026
PubMed
Summary

Host immune responses and Mycobacterium tuberculosis (Mtb) genetic diversity drive tuberculosis (TB) pathogenesis. This study identifies the neutrophil-to-T cell ratio and granulocyte-monocyte progenitor expansion as key drivers of TB immunopathology, offering new therapeutic targets.

Keywords:
host susceptibilityinbred mouse modelsmycobacterium tuberculosisneutrophil-to-T cell ratiotype I interferon

More Related Videos

Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish
07:00

Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish

Published on: October 8, 2018

11.3K
A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
10:10

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Published on: October 5, 2015

19.5K

Related Experiment Videos

Last Updated: Mar 10, 2026

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei
09:02

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei

Published on: February 17, 2014

20.3K
Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish
07:00

Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish

Published on: October 8, 2018

11.3K
A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
10:10

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Published on: October 5, 2015

19.5K

Area of Science:

  • Immunology
  • Infectious Diseases
  • Genetics

Background:

  • Tuberculosis (TB) pathogenesis involves complex host immune responses and Mycobacterium tuberculosis (Mtb) genetic diversity.
  • Understanding host determinants of TB immunopathology is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate host factors contributing to TB immunopathology using a comparative analysis of inbred mouse strains infected with Mtb.
  • To identify key cellular and molecular mechanisms driving TB severity and pathology.

Main Methods:

  • Comparative analysis of inbred mouse strains (C3H/HeJ, A/J, C57BL/6) infected with virulent Mtb K strain.
  • Assessment of pulmonary bacterial burden, lung pathology, immune cell infiltration (neutrophils, T cells), and progenitor cell populations (GMPs).
  • Intervention studies including neutrophil depletion, type I IFN blockade, IL-10 receptor blockade, and BCG vaccination.

Main Results:

  • C3H/HeJ and A/J mice showed increased susceptibility to TB, with higher bacterial loads and lung pathology.
  • Increased disease severity correlated with neutrophilic infiltration, elevated G-CSF, bone marrow GMP expansion, and a high pulmonary neutrophil-to-T cell (N/T) ratio.
  • Neutrophil depletion and type I IFN blockade significantly reduced disease severity.
  • Strain-specific interventions (IL-10R blockade, aging, BCG vaccination) modulated disease severity by restoring N/T ratios and normalizing GMP levels.

Conclusions:

  • The pulmonary N/T ratio and GMP expansion are central drivers of TB immunopathology, linked to type I IFN signaling and neutrophil-mediated inflammation.
  • Targeting neutrophil recruitment and type I IFN signaling may ameliorate TB severity.
  • Host genetic background influences susceptibility and response to interventions, highlighting the need for personalized approaches in TB treatment.