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Updated: May 1, 2026

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β-Cryptoxanthin Confers Radioprotection against Intestinal Injury via NRF2-Mediated Antioxidant Response and Gut

Manman Zhang1, Yingshuang Liu1,2, Wenbo Ma3

  • 1Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin Institutes of Health Science, State Key Laboratory of Advanced Medical Materials and Devices, Tianjin 300192, China.

International Journal of Biological Sciences
|March 9, 2026
PubMed
Summary

Beta-cryptoxanthin protects against radiation-induced intestinal injury by boosting antioxidant responses and restoring gut microbiota. This natural compound shows promise for clinical radioprotection strategies.

Keywords:
Gut microbiotaNRF2 signalingRadiation-induced intestinal injuryRadioprotectionβ-Cryptoxanthin

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Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
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Area of Science:

  • Radioprotection
  • Gastroenterology
  • Carotenoid research

Background:

  • Radiation-induced intestinal injury is a significant clinical challenge.
  • Current treatments for radiation injury are limited.
  • Beta-cryptoxanthin, a provitamin A carotenoid, possesses antioxidant properties.

Purpose of the Study:

  • To investigate the radioprotective effects of beta-cryptoxanthin.
  • To elucidate the underlying mechanisms of beta-cryptoxanthin's action.
  • To evaluate beta-cryptoxanthin's impact on gut microbiota.

Main Methods:

  • Oral administration of beta-cryptoxanthin in vivo and in vitro studies.
  • Assessment of NRF2-mediated antioxidant response.
  • Analysis of gut microbiota composition and metabolites.
  • Cellular studies on intestinal epithelial cells (MODE-K).
  • Investigation of AMPK-GSK3β signaling pathway.

Main Results:

  • Beta-cryptoxanthin alleviated radiation-induced intestinal injury in vivo.
  • Radioprotective effects were dependent on NRF2 activation.
  • Gut microbiota composition and short-chain fatty acid (SCFA) levels were restored.
  • In vitro, beta-cryptoxanthin enhanced cell viability and reduced ROS, apoptosis, and DNA damage.
  • The AMPK-GSK3β signaling axis was activated, promoting NRF2 nuclear translocation.

Conclusions:

  • Beta-cryptoxanthin demonstrates significant radioprotective potential against intestinal injury.
  • Dual mechanisms involve NRF2 activation and gut microbiota restoration.
  • Beta-cryptoxanthin represents a promising candidate for clinical radioprotection.