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  3. Multicomponent Oxicam-metformin Salts: Toward A Strategy For Enhancing Solubility And Stability.
  1. Home
  3. Multicomponent Oxicam-metformin Salts: Toward A Strategy For Enhancing Solubility And Stability.

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Multicomponent Oxicam-Metformin Salts: Toward a Strategy for Enhancing Solubility and Stability.

Estephany Muñoz-Hernández1,2, Carolina Alarcón-Payer3, Antonio Frontera4

  • 1Laboratorio de Estudios Cristalográficos, IACT-CSIC, Avda. de las Palmeras 4, 18100 Armilla, Spain.

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View abstract on PubMed

Summary
This summary is machine-generated.

New oxicam-metformin salts were created to improve drug properties. These pharmaceutical multicomponent materials enhance stability and solubility for combination therapies, offering a rational design framework.

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Area of Science:

  • Materials Science
  • Pharmaceutical Chemistry
  • Solid-State Chemistry

Background:

  • Drug-drug pharmaceutical multicomponent materials (PMMs) are key for modulating drug properties and enabling combination therapy.
  • Oxicams (piroxicam, meloxicam, tenoxicam) are nonsteroidal anti-inflammatory drugs with potential for combination therapy.
  • Metformin (MTF) is a widely used antidiabetic drug.

Purpose of the Study:

  • To prepare and characterize novel oxicam-metformin (MTF) salts.
  • To investigate the role of supramolecular synthons in salt formation and structure-property relationships.
  • To evaluate the impact of these salts on drug stability, solubility, and fluorescence.

Main Methods:

  • Synthesis and full characterization of oxicam-MTF salts.
  • X-ray diffraction and computational studies for structural analysis.
  • Stability, aqueous solubility, and fluorescence spectroscopy analyses.

    • Main Results:

    • New oxicam-MTF salts were successfully prepared and characterized.
    • Supramolecular synthons were identified as crucial for directing salt formation and influencing molecular packing.
    • The novel salts enhanced MTF stability and protected piroxicam (PRX) from hydration.
    • MTF incorporation increased oxicam solubility, while salt formation moderated MTF's excessive solubility.
    • Significant changes in fluorescence behavior were observed due to functional group interactions within the salt frameworks.

    Conclusions:

    • This study expands the range of known oxicam-MTF salts.
    • The findings provide a rational basis for designing solid forms with improved physicochemical properties.
    • These PMMs offer a promising strategy for developing enhanced combination therapies.