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Albuminuria Linked with Interstitial Myocardial Fibrosis At The Population Level: The Multi-Ethnic Study of

Omar Chehab1, Ashkan Abdollahi1, Ralph Zeitoun1

  • 1Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.

European Journal of Preventive Cardiology
|March 9, 2026
PubMed

Insights

Elevated albuminuria, a marker for cardiovascular disease, is linked to subclinical myocardial fibrosis in the general population. This association is stronger in men, prediabetics, and diabetics, independent of traditional risk factors.

Area of Science:

  • Cardiology
  • Nephrology
  • Biomarkers

Background:

  • Albuminuria is a known cardiovascular disease (CVD) marker in diabetic and non-diabetic individuals.
  • The relationship between albuminuria and myocardial fibrosis in the general population is not well understood.

Purpose of the Study:

  • To investigate the association between albuminuria and subclinical myocardial fibrosis.
  • To explore these associations across different sex and diabetes status groups.

Main Methods:

  • Utilized data from 2,112 participants in the MESA cohort with urine albumin-creatinine ratio (ACR) and cardiac magnetic resonance (CMR) with T1-mapping.
  • Assessed associations between albuminuria/ACR and extracellular volume (ECV), native T1-time, and myocardial scar using multivariable regression models.

Main Results:

  • Higher albuminuria and ACR were associated with increased ECV and native T1-time, indicating greater myocardial fibrosis.
  • These associations were more pronounced in men, prediabetics, and diabetics.
  • No significant association was found between albuminuria/ACR and myocardial scar.

Conclusions:

  • Elevated albuminuria is linked to subclinical myocardial fibrosis in a community setting, independent of traditional cardiovascular risk factors.
  • The association between albuminuria and myocardial fibrosis is more prominent in males, prediabetics, and diabetics.
Abstract

Keywords:
AlbuminuriaT1 mappinggenderinterstitial myocardial fibrosismagnetic resonance imagingmyocardial scarprediabetestype two diabetes meillitus

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