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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

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SPR-Amplified TiO₂-NanoMXene Heterojunction for Ultrasensitive Contactless Human Activity Recognition.

Yan Wang^1,2,3, Chong Li^1,4,5, Shiya Qi^1,2,3

¹College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.

Analytical Chemistry

|March 9, 2026

Summary

This study introduces a novel fiber-optic sensor for contactless human activity recognition (HAR) using moisture signatures. The plasmon-amplified TiO2-nanoMXene heterojunction offers ultrahigh sensitivity and rapid response for advanced intelligent systems.

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Area of Science:

Materials Science
Nanotechnology
Sensor Technology

Background:

Contactless human activity recognition (HAR) is crucial for intelligent systems.
Existing vision/inertial sensors face reliability and privacy issues.
Moisture sensing is an alternative but limited by sensitivity and response time.

Purpose of the Study:

To develop a novel moisture-sensing paradigm for advanced HAR.
To overcome limitations of current moisture-sensing technologies.
To achieve ultrahigh sensitivity, rapid response, and scalability in moisture detection.

Main Methods:

Fabrication of a plasmon-amplified TiO2-nanoMXene heterojunction on a fiber-optic tip.
Utilizing surface plasmon resonance (SPR) for light-activated catalysis.
Leveraging a self-reinforcing feedback loop for signal amplification.

Main Results:

The sensor demonstrates ultrahigh sensitivity to trace moisture.
Achieved fast response and recovery times with minimal hysteresis.
Exhibited robust environmental resilience.
Successfully validated for contactless finger sensing, diaper wetness monitoring, and respiratory analysis.

Conclusions:

The developed fiber-optic moisture sensor represents a new paradigm for contactless HAR.
The plasmon-amplified heterojunction enables sensitive, rapid, and reliable moisture detection.
This technology has transformative potential in healthcare and intelligent systems.