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Updated: Mar 10, 2026

A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats
Published on: August 19, 2018
Physiology of the kynurenine pathway and its implications in CNS disorders
Qi Zhang1, Yu-Hui Tang2, Xiao-Qing Tang1,3
1Institute of Neuroscience and Department of Physiology, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, P. R. China.
Abstract:
The kynurenine pathway (KP), a crucial route of tryptophan (TRP) catabolism, has emerged as a focal point of investigation because of its complex involvement in regulating central nervous system (CNS) function. This metabolic pathway, which operates in various cell types within the CNS, closely links immune responses, neurotransmission, and neuroinflammation. This review provides an in-depth exploration of the KP, delineating its enzymatic constituents, metabolite profiles, and multifarious roles in sustaining CNS homeostasis, with potential implications for neuropathological conditions including Alzheimer's disease (AD), Parkinson's disease (PD), major depressive disorder (MDD), and schizophrenia (SCZ). In addition to the roles of the KP in the pathogenesis of the abovementioned diseases, the related advancements in treatment are discussed.
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