Related Experiment Video
Updated: Mar 10, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
Published on: January 9, 2026
[From the history of pancreatology and pancreatitis classification]
E A Dubtsova1, L V Vinokurova1
1Loginov Moscow Clinical Scientific Center.
Abstract:
The retrogastric location, small size and soft consistency of the pancreas were the reason for the late discovery of the physiology of this organ. The first information about the anatomy and physiology of the pancreas appeared only in the 16th-17th centuries. The role of the pancreas in digestion was studied in the 18th-19th centuries, its participation in carbohydrate metabolism - in the 19th century, and insulin was discovered in the first half of the 20th century. Clinical signs of pancreatitis were first described in the early 19th century, but diagnosis of this disease still presents certain difficulties. The same can be said about the classification of pancreatitis. Due to the variety of etiological factors and clinical manifestations of acute and, especially, chronic pancreatitis, a single universal classification of pancreatitis has not yet been created, despite repeated attempts and existing classifications.
Related Concept Videos
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Chronic Pancreatitis II: Collaborative Care
Assessment:
Acute Pancreatitis II: Clinical Manifestations and Management
Pancreas
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short...
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...

