Beneficial effects of a departmental protocol to reduce intensive care hypernatremia: an observational...

Dysnatremia is a common electrolyte disturbance in critically ill patients that is associated with increased mortality. There are a few recommendations for the prophylaxis and treatment of intensive-care-acquired hypernatremia, but hardly any studies and no randomized trials.

An observational before-and-after study investigating the introduction of a departmental protocol between July 2019 and July 2023 in a surgical intensive care unit of a university hospital to prevent the development of hypernatremia in the intensive care unit. The departmental protocol advised the use of free water either enteral or in the form of glucose 5% intravenously and the use of certain diuretics starting even before signs of hypernatremia appeared.

In total, 10,656 patients were analyzed. The incidence of hypernatremia with sodium >150 mmol/L was markedly reduced from 13.1% to 8.9% (P<0.001) before and after implementation of the protocol. The measures, in particular enteral free fluid and glucose 5%, were used more frequently during the period after introduction. After propensity score matching and logistic regression analysis, at least an association with reduced mortality was observed following the introduction of the departmental protocol (OR 0.88 [95% CI 0.78-0.99], P=0.031). The effects varied in subgroups such as cardiac surgery, neurosurgery, patients with septic shock, COVID-19 pneumonia or acute kidney injury.

With a departmental protocol, the incidence of hypernatremia may be reduced and even outcome may be improved in subgroups, such as cardiac surgery and acute kidney injury patients.