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On-Chip Pathogens Enrichment and Detection Using Dual Vortex-Enhanced Acoustofluidic Tornado.

Wei Wei¹, Ke Jin¹, Bingnan Wang¹

¹State Key Laboratory of Precision Measuring Technology & Instruments, Tianjin University, Tianjin 300072, China.

|March 9, 2026

Summary

This summary is machine-generated.

This study introduces the Dual Vortex-Enhanced Acoustofluidic Tornado (D-VEAT), a novel microfluidic device for rapid and efficient pathogen enrichment. The D-VEAT system significantly improves pathogen detection sensitivity across a wide size range.

Keywords:

acoustofluidic gigahertz bulk acoustic wave nanometer scale on-chip pathogen enrichment

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Area of Science:

Biomedical Engineering
Microfluidics
Acoustofluidics

Background:

Pathogen detection is crucial for global health but hindered by low concentrations in samples.
Existing acoustofluidic platforms face limitations in efficiently enriching diverse pathogen sizes.
Continuous-flow operation and broad-range capture remain challenges for current technologies.

Purpose of the Study:

To develop a novel acoustofluidic lab-on-a-chip platform for broad-range pathogen enrichment.
To enhance pathogen capture efficiency and detection sensitivity using a unique vortex dynamics.
To overcome limitations of existing systems in handling varying pathogen sizes and concentrations.

Main Methods:

Integration of a geometrically optimized dual-triangular gigahertz (GHz) bulk acoustic wave resonator.
Creation of a stable, three-dimensional dual acoustofluidic vortex structure.
Utilizing a solid-free fluidic capture strategy with adaptive vortex dynamics.

Main Results:

Achieved >99% capture efficiency for 2 μm particles and >12x fluorescence enhancement for 100 nm particles.
Demonstrated detection limits of 1 × 10^3 CFU/mL for bacteria and 2 × 10^4 PFU/mL for coronavirus in <5 min.
Showcased accommodation of pathogen concentrations from 10^3 to 10^8 CFU/mL without channel blockage.

Conclusions:

The Dual Vortex-Enhanced Acoustofluidic Tornado (D-VEAT) offers rapid, efficient, and broad-range pathogen enrichment.
This technology enables sensitive pathogen detection from ultra-low volume samples.
D-VEAT presents a promising solution for low-cost, reusable diagnostics in various settings.