Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

5.5K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
5.5K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

41.6K
Overview
41.6K
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

10.3K
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
10.3K
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

3.3K
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
3.3K
Base Excision Repair01:54

Base Excision Repair

27.2K
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
27.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional and omics-based rationale for the induction of BRCAness by androgen receptor pathway inhibitors to sensitize prostate cancer to PARP inhibition, regardless of HRR status.

British journal of cancer·2026
Same author

ERG orchestrates a dedifferentiation-senescence-inflammation triad in prostate cancer.

Molecular cancer research : MCR·2026
Same author

EMETPRO: a multicentric, international, retrospective analysis evaluating patients with metastatic hormone-sensitive prostate cancer with early progression.

Prostate cancer and prostatic diseases·2026
Same author

Combined ctDNA and serum PSA for dynamic monitoring of metastatic prostate cancer starting first-line treatment: a prospective national cohort study.

Nature cancer·2026
Same author

SET1B Drives Sustained HIF activity and Disease Progression in Clear Cell Renal Cell Carcinoma.

Cancer research·2026
Same author

Intercepting YAP Activation in Prostate Cancer Blocks Neuroendocrine Progression.

Cancer research·2026

Related Experiment Video

Updated: Mar 11, 2026

Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells
05:18

Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells

Published on: June 9, 2020

11.9K

Exploring DNA Damage Repair Therapeutics in Prostate Cancer beyond BRCAness.

Fabrizio Di Costanzo1,2, Jack Williamson2, Craig N Robson2

  • 1Department of Medical Oncology, Università degli Studi di Napoli Federico II, Naples, Italy.

Molecular Cancer Therapeutics
|March 9, 2026
PubMed
Summary
This summary is machine-generated.

Prostate cancers with DNA repair gene alterations are aggressive. Poly (ADP-ribose) polymerase (PARP) inhibitors show promise beyond BRCA mutations, necessitating improved patient selection for better outcomes.

More Related Videos

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
06:44

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging

Published on: April 28, 2021

4.7K
Visualization of DNA Repair Proteins Interaction by Immunofluorescence
07:55

Visualization of DNA Repair Proteins Interaction by Immunofluorescence

Published on: June 26, 2020

11.3K

Related Experiment Videos

Last Updated: Mar 11, 2026

Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells
05:18

Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells

Published on: June 9, 2020

11.9K
Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
06:44

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging

Published on: April 28, 2021

4.7K
Visualization of DNA Repair Proteins Interaction by Immunofluorescence
07:55

Visualization of DNA Repair Proteins Interaction by Immunofluorescence

Published on: June 26, 2020

11.3K

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Prostate cancers with DNA damage response (DDR) gene alterations often exhibit aggressive behavior and poor survival.
  • Poly (ADP-ribose) polymerase (PARP) enzyme inhibitors (PARPi) are effective in prostate cancers with BRCA1/2 mutations.
  • The efficacy of PARPi in prostate cancers with other DNA repair gene alterations is under investigation.

Purpose of the Study:

  • To review common genomic aberrations in prostate cancer DNA repair pathways.
  • To discuss strategies for improving patient selection for PARPi therapy.
  • To explore novel DNA repair pathway inhibitors and their potential to overcome treatment resistance.

Main Methods:

  • Genomic analysis of prostate cancer DNA repair pathways.
  • Literature review of current and emerging PARPi and other DNA repair inhibitors.
  • Discussion of clinical development and patient stratification strategies.

Main Results:

  • Identified frequent genomic aberrations in prostate cancer DNA repair pathways.
  • Highlighted the need for refined patient selection criteria for PARPi treatment.
  • Presented emerging therapeutic strategies targeting DNA repair pathways.

Conclusions:

  • Targeting DNA repair pathways is a key strategy in advanced prostate cancer.
  • Optimizing patient selection beyond BRCA1/2 mutations is crucial for PARPi efficacy.
  • Novel inhibitors offer potential to address primary and secondary resistance in prostate cancer treatment.