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Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
[Update on Vascular Malformations: From the Patient's Perspective to Modern Treatment Approaches]
1Division of Angiology, Swiss Cardiovascular Center, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
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Vascular malformations often impair patients' quality of life for many years, frequently following a prolonged period of misdiagnoses and unsuccessful treatments. Advances in genetic diagnostics have fundamentally reshaped classification and opened the door to individualized therapeutic approaches. In addition to established modalities such as sclerotherapy, embolization, and surgery, targeted pharmacologic therapies - including mTOR and MEK inhibitors - are expanding the treatment spectrum. Increasing emphasis is also placed on a patient-centered perspective, with systematic assessment of symptoms, functional limitations, and psychosocial burden. For clinical practice, this means recognizing red flags early, referring patients promptly to specialized centers, and ensuring interdisciplinary care focused on quality of life.
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