Related Experiment Video

Updated: Mar 11, 2026

Preparation of Mitochondria from Ovarian Cancer Tissues and Control Ovarian Tissues for Quantitative Proteomics Analysis
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Preparation of Mitochondria from Ovarian Cancer Tissues and Control Ovarian Tissues for Quantitative Proteomics Analysis

Published on: November 18, 2019

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Mitochondrial metabolic vulnerabilities in high-grade serous ovarian cancer

Anjali Prasad1, Scott H Kaufmann2, Arun Kanakkanthara2

  • 1Department of Oncology, Mayo Clinic, Rochester, MN 55905, United States of America.

Biochimica Et Biophysica Acta. Reviews on Cancer
|March 9, 2026
PubMed

Insights

High-grade serous ovarian cancer relies on mitochondrial metabolism, creating a vulnerability. Targeting this metabolism offers a promising strategy to overcome treatment resistance and eliminate cancer cells.

Area of Science:

  • Oncology
  • Cell Metabolism
  • Cancer Therapeutics

Background:

  • High-grade serous ovarian cancer (HGSOC) exhibits significant reliance on mitochondrial metabolism.
  • This metabolic adaptation is associated with disease progression, therapeutic resistance, and immune evasion.

Purpose of the Study:

  • To review the molecular mechanisms of mitochondrial metabolic rewiring in HGSOC.
  • To outline the role of metabolic reprogramming in HGSOC progression, immune evasion, and treatment resistance.
  • To discuss challenges and strategies for exploiting metabolic vulnerabilities in HGSOC therapy.

Main Methods:

  • Literature review of molecular mechanisms in HGSOC metabolism.
  • Analysis of the role of mitochondrial metabolism in HGSOC progression and treatment resistance.
  • Discussion of current and emerging therapeutic strategies targeting mitochondrial metabolism.

Main Results:

  • Mitochondrial metabolism is a key driver of HGSOC progression and resistance.
  • Metabolic rewiring contributes to immune evasion in the HGSOC microenvironment.
  • Several agents targeting mitochondrial metabolism are in clinical trials or repurposed for cancer therapy.

Conclusions:

  • Targeting mitochondrial metabolism represents a promising therapeutic vulnerability in HGSOC.
  • Exploiting metabolic remodeling could lead to more effective HGSOC treatments.
  • Further research is needed to overcome challenges in translating metabolic targeting strategies into clinical practice.
Keywords:
Fatty acid β-oxidationHigh-grade serous ovarian cancerMitochondrial metabolismOxidative phosphorylationTCA cycleTumor metabolic reprogramming

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